Manuel Müller

Biography

Manuel Müller’s interdisciplinary research group develops and applies chemical biology tools, including peptide and protein synthesis, to investigate the function of post-translational modifications (PTMs). We are particularly interested in PTMs that involve the polypeptide backbone and how these (and more traditional modifications) control cellular life and death decisions.

Manuel studied biochemistry at ETH Zürich and stayed on to pursue a PhD with Prof. Don Hilvert on primordial enzymes and their foldamer mimetics. His work was supported by a fellowship from the Scholarship Fund of the Swiss Chemical Industry and awarded with the ETH Medal. He then joined Prof. Tom Muir’s lab at Rockefeller as a postdoctoral fellow (Swiss National Science Foundation) and moved with the group to Princeton University in 2011. There he deployed “designer chromatin” to elucidate how chromatin-modifying enzymes contribute to epigenetic phenomena and diseases. In 2016, he joined the recently re-established chemistry department at King’s College London as a Wellcome Trust/Royal Society Sir Henry Dale Fellow. In 2021, he was recognised with the RSC Norman Heatley Award.

For more information on Manuel’s research please visit this Research Portal page at https://www.muellerlab-kcl.com.